Highlights Publication Wall DST & ResDMPK

Discovery Science MS Biomarker

• Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injury
• mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes
• Evaluating Antibody Pharmacokinetics as Prerequisite for Determining True Efficacy as Shown by Dual Targeting of PD-1 and CD96
• Prostaglandin Metabolites Analysis in Urine by LC-MS/MS

Bioanalysis

• An ultrafast and flexible liquid chromatography/tandem mass spectrometry system paves the way for machine learning driven in vivo sample processing in early drug discovery
• Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry
• Ultrahigh-Throughput ESI-MS: Sampling Pushed to Six Samples per Second by Acoustic Ejection Mass Spectrometry

Target Discovery Sciences

• Deep learning-based quantification of NAFLD/NASH progression in human liver biopsies
• Learning image representations for anomaly detection: Application to discovery of histological alterations in drug development
• Mapping administration route-dependent transduction profiles of commonly used AAV variants in mice by barcode amplicon sequencing
• Spatial transcriptomic characterization of pathologic niches in IPF

In vitro ADME

Research PK

PK/PD